Episode 15: Vaginal versus Intramuscular Progesterone
The results were very disappointing to many women and couples and to those who care for them. We had all hoped that the trial would show that progesterone is an effective treatment for those considering pregnancy after previous unexplained losses, but sadly it did not. The study of women with previously unexplained recurrent miscarriage showed that those who received progesterone treatment in early pregnancy were no less likely to miscarry than those who received a placebo or dummy treatment. This was true whatever their age, ethnicity, medical history and pregnancy history. Nearly two-thirds of the women in the trial had their baby, whether they had progesterone or the placebo. The first is that nearly two-thirds of the women in the trial had their baby, whether they had progesterone or the placebo. So even without treatment, the chances of a healthy pregnancy after unexplained recurrent miscarriage are better than some might expect. The trial results also showed that there were no harmful effects of progesterone treatment for women or for their babies. That is very important information for women taking progesterone for other reasons, such as fertility treatment or for those taking part in other trials. Another important finding for women who do take progesterone in early pregnancy is that there was no sign that progesterone treatment simply delayed the process of miscarriage. Amongst those who miscarried, there was no difference between the treated and untreated women in the stage at which they miscarried. And while researchers will continue to explore and test other treatments that might reduce the risk for women who are pregnant after a history of repeated miscarriages, there are interesting new findings about progesterone from another source.
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